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CM 346

CAS No. 173352-21-1

CM 346( Obenoxazine )

Catalog No. M12632 CAS No. 173352-21-1

Afobazole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 87 In Stock
25MG 196 In Stock
50MG 291 In Stock
100MG 435 In Stock
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Biological Information

  • Product Name
    CM 346
  • Note
    Research use only, not for human use.
  • Brief Description
    Afobazole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.
  • Description
    Afobazole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.(In Vitro):Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
  • In Vitro
    Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
  • In Vivo
    ——
  • Synonyms
    Obenoxazine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    173352-21-1
  • Formula Weight
    307.41
  • Molecular Formula
    C15H21N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in DMSO
  • SMILES
    CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1
  • Chemical Name
    4-(2-((5-ethoxy-1H-benzo[d]imidazol-2-yl)thio)ethyl)morpholine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Behensky AA, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):458-67.
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